An advanced platform for effective design and screening of therapeutic protein candidates

The many challenges of using biologics for therapeutic purposes clearly indicate a requirement for de novo development of novel therapeutic proteins. Protein/Target Hunter is a platform utilizing AI simulation coupled with phage display technology for rapid development of novel proteins.

In the field of tumor immunotherapy, tumor antigen escape and the harsh tumor microenvironment (TME) present challenges that would require the development of novel tumor-targeting molecules such as single chain variable fragments (scFv) and nanobodies, or novel engineered protein modulators. Therefore, in collaboration with TMU BIOMED Gloria, GenomeFrontier utilized this platform to successfully develop a number of therapeutic protein candidates for specifically targeting tumor antigens and/or modulating the TME. A brief schematic diagram illustrating how Protein/Target Hunter achieves this is shown in Figure 1: